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Peer Reviewed 

Induction of apically mistrafficked EREG disrupts epithelial polarity via aberrant EGFR signaling.

Singh B, Bogatcheva G, Krystofiak E, McKinley ET, Hill S, Rose KL, Higginbotham JN, Coffey RJ. 

Journal of Cell Science. 134(18):jcs255927, 2021. 

PMID: 34406412

*Accompanied by “First Person” interview for first author in Journal of Cell Science 

*Highlighted in the American Cancer Society’s Podcast Theory Lab

Cell surface integrin a5 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.

Starchenko A, Graves-Deal R, Brubaker D, Li C, Yang Y, Singh B, Coffey RJ, Lauffeburger DA.

Integrative Biology. 13:153-166, 2021.

PMID: 34037774

Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry.

Wen X, Ou Y-C, Bogatcheva G, Thomas G, Mahadevan-Jansen A, Singh B, Lin EC, Bardhan R.

Chemical Science 11:9863-9874, 2020.

PMID: 34094246


Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.

Cao Z*, Singh B*, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ.

Traffic 20:357-368, 2019. *Co-first author

PMID: 30941853

Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer.

Graves-Deal R, Bogatcheva G, Rehman S, Lu Y, Higginbotham JN, Singh B*

Oncotarget 10:1320-1333, 2019. *Corresponding author

PMID: 30863492

lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.

Lu Y, Zhao Z, Liu Q, Li C, Graves-Deal R, Cao Z, Singh B, Franklin JL, Wang J, Hu H, Yang M, Yeatman TJ, Lee E, Saito-Diaz K, Hinger S, Patton JG, Chung CH, Emmrich S, Klusmann J-H, Fan D, Coffey RJ.

Nature Medicine 23:1331-1341, 2017.

PMID: 29035371

Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer.

Li C*, Singh B*, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Khan MP, Milne GL, Zhao S, Ayers GD, Washington MK, Yeatman TJ, McDonald OG, Liu Q, and Coffey RJ.

Proceedings of the National Academy of Sciences of the USA (PNAS) 114:E2852-E2861, 2017. *Co-first author

PMID: 28320945

Clustering of integrin alpha 5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells.

Starchenko A, Graves-Deal R, Yang YP, Li C, Zent R, Singh B, and Coffey RJ.

Molecular Biology of the Cell 28:1288-1300, 2017.

PMID: 28356422

Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.

Singh B*, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, and Coffey RJ.

Journal of Cell Science 128:3444-3455, 2015. *Corresponding author

PMID: 26272915

*Highlighted in Journal of Cell Science “In this issue”, and recommended by Faculty of 1000 


Transformation of polarized epithelial cells by apical mistrafficking of epiregulin.

Singh B, Bogatcheva G, Washington MK, and Coffey RJ.

Proceedings of the National Academy of Sciences of the USA (PNAS) 110:8960-8965, 2013.

PMID: 23671122

Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin.

Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzales A, Folsch H, and Coffey RJ.

Traffic 12:1793-1804, 2011.

PMID: 21917092

UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines.

Singh B, Schneider M, Knyazev P, and Ullrich A. 

International Journal of Cancer 124:531-9, 2009.

PMID: 19003995

Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB.

Chopra P, Singh B, Singh R, Vohra R, Koul A, Meena LS, Koduri H, Ghildiyal M, Deol P, Das TK, Tyagi AK, and Singh Y. 

Biochemical and Biophysical Research Communications 311:112-20, 2003.

PMID: 14575702

Review Articles

EGF receptor ligands: recent advances

Singh B, Carpenter G, and Coffey RJ.

F1000Research pii: F1000 Faculty Rev-2270, 2016.

PMID: 27635238

From wavy hair to naked proteins: The role of transforming growth factor alpha in health and disease.

Singh B and Coffey RJ.

Seminars in Cell and Developmental Biology 28:12-21, 2014. Review.

PMID: 24631356

Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells.

Singh B and Coffey RJ.

Annual Review of Physiology 76:275-300, 2014. Review.

PMID: 24215440

Science Outreach

Characterization of the downstream effects of apical mistrafficking of epiregulin and potential for transformation in polarized epithelial cells.

Rehman S, Bogatcheva G, Coffey RJ, and Singh B. 

Vanderbilt science outreach journal: Young Scientist 6:33-36, 2016.

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