Publications

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention.

Li Q, Song Q, Chen Z, Choi J, Moreno V, Ping J, Wen W, Li C, Shu X, Yan J, Shu XO, Cai Q, Long J, Huyghe JR, Pai R, Gruber SB, Yang Y, Casey G, Wang X, Toriola AT, Li L, Singh B, Lau KS, Zhou L, Zhang Z, Wu C, Peters U, Zheng W, Long Q, Yin Z, Guo X.

Am J Hum Genet. 2025 Dec 2:S0002-9297(25)00433-1. Online ahead of print.

PMID: 41338217

 

Pan-cancer analyses reveal disparities in tumor genomic profiles by race/ethnicity, age, and sex.

​Wen W, Choi J, Singh B, Li L, Toriola AT, Ciombor KK, Park BH, Shu X, Idrees K, Zheng W, Guo X. 

Cancer Epidemiology, Biomarkers & Prevention. 2025 Dec 1;34(12):2208-2218. Online ahead of print.

PMID: 40996301

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A high-throughput 3D screen identifies drugs that induce epithelial polarity and enhance responsiveness to chemotherapy in colorectal cancer.

Harmych SJ, Hasaka TP, Sievers CK, Kang SW, Jones VT, Zhao Z, Kovtun O, Wahoski CC, Lau KS, Coffey RJ, Bauer JA, Singh B*.

Communications Biology. 2025 Aug 22;8(1):1261. *Corresponding author

PMID: 40847193

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Metabolic response to small molecule therapy in colorectal cancer tracked with Raman spectroscopy and metabolomics.

Cutshaw GP, Joshi N, Wen X, Quam E, Hassan N, Bogatcheva G, Uthaman S, Waite J, Sarkar S, Singh B*, Bardhan R*.

Angewandte Chemie International Edition. 2024 Oct 21;63(43):e202410919. *Co-corresponding author

PMID: 38995663​

 

Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention and intervention.

Li Q, Song Q, Chen Z, Choi J, Moreno V, Ping J, Wen W, Li C, Shu X, Yan J, Shu XO, Cai Q, Long J, Huyghe JR, Pai R, Gruber SB, Casey G, Wang X, Toriola AT, Li L, Singh B, Lau KS, Zhou L, Wu C, Peters U, Zheng W, Long Q, Yin Z, Guo X.

medRxiv [Preprint]. 2024 May 31:2024.05.29.24308170.

PMID: 38853880

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Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer.

Jones VT, Graves-Deal R, Cao Z, Bogatcheva G, Ramirez MA, Harmych SJ, Higginbotham JN, Sharma V, Damalanka VC, Wahoski C, Joshi N, Roland JT, Ayers GD, Liu Q, Coffey RJ, Janetka JW, Singh B*

Cellular and Molecular Life Sciences. 2024;81(1):28. *Corresponding author

PMID: 38212428

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Monitoring Metabolic Changes in Response to Chemotherapies in Cancer with Raman Spectroscopy and Metabolomics.

Cutshaw G, Hassan N, Uthaman S, Wen X, Singh B, Sarkar A, Bardhan R.

Analytical Chemistry. 2023;95(35):13172-13184.

PMID: 37605298

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A CGA/EGFR/GATA2 positive feedback circuit confers chemoresistance in gastric cancer.

Cao T, Lu Y, Wang Q, Qin H, Li H, Guo H, Ge M, Glass SE, Singh B, Zhang W, Dong J, Du F, Qian A, Tian Y, Wang X, Li C, Wu K, Fan D, Nie Y, Coffey RJ, Zhao X.

​Journal of Clinical Investigation. 2022;132(6):e154074.

PMID: 35289315​​​

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Induction of apically mistrafficked EREG disrupts epithelial polarity via aberrant EGFR signaling.

Singh B, Bogatcheva G, Krystofiak E, McKinley ET, Hill S, Rose KL, Higginbotham JN, Coffey RJ. 

Journal of Cell Science. 134(18):jcs255927, 2021. 

PMID: 34406412

*Accompanied by “First Person” interview for first author in Journal of Cell Science 

*Highlighted in the American Cancer Society’s Podcast Theory Lab

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Cell surface integrin a5 clustering negatively regulates receptor tyrosine kinase signaling in colorectal cancer cells via glycogen synthase kinase 3.

Starchenko A, Graves-Deal R, Brubaker D, Li C, Yang Y, Singh B, Coffey RJ, Lauffeburger DA.

Integrative Biology. 13:153-166, 2021.

PMID: 34037774

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Probing metabolic alterations in breast cancer in response to molecular inhibitors with Raman spectroscopy and validated with mass spectrometry.

Wen X, Ou Y-C, Bogatcheva G, Thomas G, Mahadevan-Jansen A, Singh B, Lin EC, Bardhan R.

Chemical Science. 11:9863-9874, 2020.

PMID: 34094246

 

Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-α for epidermal growth factor receptor transactivation.

Cao Z*, Singh B*, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ.

Traffic. 20:357-368, 2019. *Co-first author​

PMID: 30941853

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Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer.

Graves-Deal R, Bogatcheva G, Rehman S, Lu Y, Higginbotham JN, Singh B*. 

Oncotarget. 10:1320-1333, 2019. *Corresponding author

PMID: 30863492

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lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.

Lu Y, Zhao Z, Liu Q, Li C, Graves-Deal R, Cao Z, Singh B, Franklin JL, Wang J, Hu H, Yang M, Yeatman TJ, Lee E, Saito-Diaz K, Hinger S, Patton JG, Chung CH, Emmrich S, Klusmann J-H, Fan D, Coffey RJ.

Nature Medicine. 23:1331-1341, 2017.

PMID: 29035371

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Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer.

Li C*, Singh B*, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Khan MP, Milne GL, Zhao S, Ayers GD, Washington MK, Yeatman TJ, McDonald OG, Liu Q, and Coffey RJ.

Proceedings of the National Academy of Sciences of the USA (PNAS). 114:E2852-E2861, 2017. *Co-first author

PMID: 28320945

​​

Clustering of integrin alpha 5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells.

Starchenko A, Graves-Deal R, Yang YP, Li C, Zent R, Singh B, and Coffey RJ.

Molecular Biology of the Cell. 28:1288-1300, 2017.

PMID: 28356422

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Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin.

Singh B*, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, and Coffey RJ.

Journal of Cell Science. 128:3444-3455, 2015. *Corresponding author

PMID: 26272915

*Highlighted in Journal of Cell Science “In this issue”, and recommended by Faculty of 1000 

 

Transformation of polarized epithelial cells by apical mistrafficking of epiregulin.

Singh B, Bogatcheva G, Washington MK, and Coffey RJ.

Proceedings of the National Academy of Sciences of the USA (PNAS). 110:8960-8965, 2013.

PMID: 23671122

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Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin.

Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzales A, Folsch H, and Coffey RJ.

Traffic. 12:1793-1804, 2011.

PMID: 21917092

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UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines.

Singh B, Schneider M, Knyazev P, and Ullrich A. 

International Journal of Cancer. 124:531-9, 2009.

PMID: 19003995

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Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB.

Chopra P, Singh B, Singh R, Vohra R, Koul A, Meena LS, Koduri H, Ghildiyal M, Deol P, Das TK, Tyagi AK, and Singh Y. 

Biochemical and Biophysical Research Communications. 311:112-20, 2003.

PMID: 14575702